Alpha thalassemia is a hemolytic anemia. In most hemolytic anemias the LD and bilirubin are increased while the haptoglobin is decreased. However, because haptoglobin binds to the alpha chain portion of hemoglobin, it usually remains at normal levels due to the absence of alpha chains in the destroyed cells.

Which set of chemistry results would most likely occur during hemolytic crisis in alpha thalassemia intermedia?

The blood glucose value is critical; negative ketones is consistent with type 2 diabetes. An elderly type 2 diabetic patient is at risk for hyperosmolar non-ketotic coma and osmolality should be measured.

A measurement of urine glucose would not be useful at this point.

A 70-year-old type 2 diabetic patient is comatose and in the emergency department. Stat blood glucose and serum ketones are ordered.

Blood Glucose: 650 mg/dL

Serum Ketones: Negative

What is the best conclusion?

HLA-DR is a MHC class II(major histocompatibility complex) surface receptor on the cellular surface which is encoded by the human leukocyte antigen complex, or HLA.

DR antigens are found in which of the following systems:

A phlebotomist draws an outpatient without wearing gloves. The outpatient displays a badge and cites the laboratory for not following the law. The outpatient is an employee of the:

An international, nonprofit organization that establishes standards of best current practice for clinical laboratories is

The Fc portion of immunoglobulin can activate the classical complement pathway, where the heavy chains, light chains, hinge regions and Fab portions cannot.

Which part of the immunoglobulin molecule is responsible for activating complement?

A key laboratory characteristic by which Mycobacterium bovis can be separated from Mycobacterium tuberculosis is:

If Kappa or Lambda is predominant and CD5 is co-expressed with CD19 (CD19/CD5 dual positive lymphocyte population), and CD23 is expressed, chronic lymphocytic leukemia is a probable diagnosis. CD19 is normally found on normal B cell populations and CD5 is normally found on mature T cell populations. However, CD5 is present on B cells in B-chronic lymphocytic leukemia or Mantle Cell Lymphoma, both abnormal B cell malignant processes.

CD23 expression is not consistent with Mantel cells as shown on the decision tree on the right.

A monoclonal B-cell population (Kappa or Lambda predominant) with expression of CD19, CD20, CD23, and co-expression of CD5 is consistent with which of the following?

The Needlestick Safety and Prevention Act requires employers to:

A slow, progressive drift of values away from the mean is called a trend. Trends occur when a particular analyte value slowly and progressively changes in one direction from one run to the next. Monitoring data for trends is part of good laboratory practice and is one indicator of many that helps laboratorians determine whether the measurement system is fucntioning appropriately.

A slow, progressive drift of values away from the mean is called a:

Transfusion of red cells of any ABO type other than O to a group O patient is of course likely to cause a hemolytic transfusion reaction.

Which of the following types of packed RBCs could be transfused to a group O patient:

Neutrophils, lymphocytes and macrophage/ monocytes can be found in all types of body fluid differentials. Bronchial cells can be found only in bronchial washings and BAL specimens. Mesothelial cells are found only in serous body fluids including pleural fluid, peritoneal fluid, and pericardial fluid.

Select the specific cells listed below that can be found in all types of body fluid.

Ammonium biurate crystalsare typically round, irregularly spiked and yellow-brown in color.

A microscopic examination of a normal urine pH 8.0 shows 2+ yellow-brown thorny spheres which are MOST probably:

A hospital chief operating officer is responsible for

Yellow stopper tubes are used for all of the following except:

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